United States securities and exchange commission logo

                          December 28, 2020

       David A. Gonyer, R.Ph.
       President and Chief Executive Officer
       Evoke Pharma, Inc.
       420 Stevens Avenue, Suite 370
       Solana Beach, CA 92075

                                                        Re: Evoke Pharma, Inc.
Statement on Form S-3
                                                            Filed December 22,
                                                            File No. 333-251614

       Dear Mr. Gonyer:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Alan
Campbell at 202-551-4224 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Matthew T. Bush, Esq.