United States securities and exchange commission logo December 28, 2020 David A. Gonyer, R.Ph. President and Chief Executive Officer Evoke Pharma, Inc. 420 Stevens Avenue, Suite 370 Solana Beach, CA 92075 Re: Evoke Pharma, Inc. Registration Statement on Form S-3 Filed December 22, 2020 File No. 333-251614 Dear Mr. Gonyer: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Alan Campbell at 202-551-4224 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Matthew T. Bush, Esq.